A convenient and efficient method for the conversion of serine and its derivatives to dehydroalanine with different bases and solvents was studied in this paper.The serine derivatives include Boc-N-L-Ser-OCH3(Ⅰ)Boc-L-Ser-(OTs)-OCH3(Ⅱ),and Boc-N-L-Ser-(Ⅰ)-OCH3(Ⅲ).