A convenient and efficient method for the conversion of serine and its derivatives to dehydroalanine with different bases and solvents was studied in this paper.The serine derivatives include Boc-N-L-Ser-OCH3（Ⅰ）Boc-L-Ser-（OTs）-OCH3（Ⅱ）,and Boc-N-L-Ser-（Ⅰ）-OCH3（Ⅲ）.
The synthesis of oestradiol compounds,which plays a very important role in biochemical test,is described in this paper.2-Hydroxide-17-deoxy-oestrone was synthesized from oestrone dy a three-step procedure:Wolff-Kishner reduction,acetylation and Dakin oxidation.(1) WolffKishner reduction: the yield of 17-deoxyestrone was 86.0%.(2)acetylation:the yield of 2-acetyl-deoxyestrone was 81.9%.(3) Dakin oxidation: the yield of 2hydroxied-17deoxy-oestrone was 91.2%
