搜索到250篇“ TMZ“的相关文章
TMZ@ZIF-8纳米粒的制备、表征及体内外抗肿瘤研究
2024年
目的制备沸石咪唑骨架(ZIF)-8纳米粒(NPs)负载替莫唑胺(TMZ)(简称TMZ@ZIF-8 NPs)药物递送系统,以增加药物在病灶的富集和抗脑胶质瘤效果。方法采用室温溶液反应法制备ZIF-8 NPs后,再采用浸渍法制备TMZ@ZIF-8 NPs药物递送系统。进行透射电镜、激光粒度及傅里叶变换红外光谱等表征和溶出实验,并进行体外及体内抗肿瘤活性实验。结果TMZ@ZIF-8 NPs制备成功,粒径为(126.23±7.92)nm,载药率为(28.79±1.26)%,72 h累积溶出速率为(72.36±3.62)%。体外抗肿瘤活性实验结果显示,ZIF-8 NPs的相对细胞存活率一直保持在90%以上;与游离的TMZ相比,TMZ@ZIF-8 NPs对C6细胞的生长、增殖表现出更优的抑制作用、更高的被摄取能力和更好的促凋亡效果。体内抗肿瘤活性实验结果显示,ZIF-8 NPs在大鼠脑部不富集,TMZ在脑部富集效果并不显著,而TMZ@ZIF-8 NPs在脑部富集效果显著。结论ZIF-8 NPs可有效负载TMZ,制备成功的TMZ@ZIF-8可提高TMZ摄取能力及抗脑胶质瘤效果。
刘婷王怡李冰辉何硕夏江朱婷
关键词:替莫唑胺PH敏感药物递送系统纳米粒
Suppression of ITPKB degradation by Trim25 confers TMZ resistance in glioblastoma through ROS homeostasis
2024年
Temozolomide(TMZ)represents a standard-of-care chemotherapeutic agent in glioblastoma(GBM).However,the development of drug resistance constitutes a significant hurdle in the treatment of malignant glioma.Although specific innovative approaches,such as immunotherapy,have shown favorable clinical outcomes,the inherent invasiveness of most gliomas continues to make them challenging to treat.Consequently,there is an urgent need to identify effective therapeutic targets for gliomas to overcome chemoresistance and facilitate drug development.This investigation used mass spectrometry to examine the proteomic profiles of six pairs of GBM patients who underwent standard-of-care treatment and surgery for both primary and recurrent tumors.A total of 648 proteins exhibiting significant differential expression were identified.Gene Set Enrichment Analysis(GSEA)unveiled notable alterations in pathways related to METABOLISM_OF_LIPIDS and BIOLOGICAL_OXIDATIONS between the primary and recurrent groups.Validation through glioma tissue arrays and the Xiangya cohort confirmed substantial upregulation of inositol 1,4,5-triphosphate(IP3)kinase B(ITPKB)in the recurrence group,correlating with poor survival in glioma patients.In TMZ-resistant cells,the depletion of ITPKB led to an increase in reactive oxygen species(ROS)related to NADPH oxidase(NOX)activity and restored cell sensitivity to TMz.Mechanistically,the decreased phosphorylation of the E3 ligase Trim25 at the S100 position in recurrent GBM samples accounted for the weakened ITPKB ubiquitination.This,in turn,elevated ITPKB stability and impaired ROS production.Furthermore,ITPKB depletion or the ITPKB inhibitor GNF362 effectively overcome TMZ chemoresistance in a glioma xenograft mouse model.These findings reveal a novel mechanism underlying TMZ resistance and propose ITPKB as a promising therapeutic target forTMZ-resistant GBM.
Yuanliang YanShangjun ZhouXi ChenQiaoli YiSongshan FengZijin ZhaoYuanhong LiuQiuju LiangZhijie XuZhi LiLunquan Sun
关键词:TMZHOMEOSTASISIMPAIRED
胶质瘤U251干细胞通过FOXO3a/β-catenin通路调控TMZ耐药性的研究
2024年
目的 探讨胶质瘤U251干细胞是否通过FOXO3a/β-catenin通路调控其对替莫唑胺(TMZ)的耐药性。方法 U251干细胞分为TMZ组(100μmol/L TMZ处理细胞)和对照组,Western blot及实时荧光定量逆转录-PCR(qRT-PCR)实验检测两组TMZ作用下FOXO3a、β-catenin、Nestin、CD133、Sox2表达情况。干细胞成球实验验证U251干细胞对TMZ的耐受情况。将FOXO3a/β-catenin干扰序列嵌入慢病毒pHY-LV-KD1.1表达载体构建重组病毒载体pHY-FOXO3a-KD、pHY-β-catenin-KD并转染U251干细胞,在TMZ作用下检测干细胞克隆球数量的变化,观察敲低FOXO3a、β-catenin对U251干细胞特性及耐药性的影响。结果 Western blot及qRT-PCR结果显示,与对照组比较,TMZ组FOXO3a、β-catenin、Nestin、CD133、Sox2蛋白表达水平升高,Nestin、CD133、Sox2 mRNA表达水平升高(P<0.05)。克隆形成实验结果显示,TMZ处理5 d后存活下来的细胞多为干细胞,说明U251干细胞可较好地耐受TMZ。敲低FOXO3a、β-catenin可导致U251干细胞群数量减少,说明其对TMZ耐药性减弱。结论 FOXO3a/β-catenin通路可调控U251干细胞特性及TMZ耐药性。
王政周艳玲许可莫菁莲
关键词:胶质瘤耐药性
诱导干细胞分化为NK细胞的试剂盒及其应用以及NK细胞联合TMZ在治疗TMZ耐药型GBM中的应用
本发明属于生物技术领域,提供了诱导干细胞分化为自然杀伤细胞的试剂盒、方法及其应用。本发明的试剂盒中采用化学成分明确的培养基、化学小分子和细胞因子,不涉及血清等容易带来批次差异等不稳定因素的物质,并且,价格上相对于已知的商...
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辅食机(TMZ
1.本外观设计产品的名称:辅食机(TMZ)。;2.本外观设计产品的用途:用于制作辅食,例如料理及搅拌食物。;3.本外观设计产品的设计要点:在于形状。;4.最能表明设计要点的图片或照片:设计2立体图1。;5.指定设计2为基...
林少群
一种骨靶向的用于递送TMZ的仿生纳米药物递送系统及其制备方法和应用
本发明涉及生物医药领域,特别是涉及一种骨靶向的用于递送TMZ的仿生纳米药物递送系统及其制备方法和应用。基于单一曲美他嗪(TMZ)在治疗肥胖相关OA疾病中存在选择性差、生物利用度低和毒副作用大等问题,本发明利用可电离脂质体...
沈舒滢梅子轩郭磊黄冬冬柳慧丽薛莲
白藜芦醇在胶质母细胞瘤TMZ化疗中的作用
2024年
胶质母细胞瘤是最具侵袭性的神经胶质瘤。肿瘤细胞对当前的替莫唑胺化疗具有耐药性,研究人员探索发现更合适的替代或辅助治疗胶质母细胞瘤的方法。白藜芦醇是一种中草药和天然多酚类化合物,具有广泛的抗肿瘤作用,已被证明可有效治疗胶质母细胞瘤。白藜芦醇通过多种机制发挥其抗肿瘤作用,如调节MGMT、凋亡途径、自噬、STAT3等。白藜芦醇与替莫唑胺联合治疗可减少耐药性。文章总结了白藜芦醇在胶质母细胞瘤替莫唑胺化疗中的作用与机制。
曹嘉轩张洪江尤昕
关键词:白藜芦醇胶质母细胞瘤替莫唑胺
Filter TMZ350 XT与Beautiful Flow Plus流动树脂及FUJI IX玻璃离子水门汀在牙颈部楔状缺损修复治疗中的应用效果
2024年
目的探析Filter TMZ350 XT、Beautiful Flow Plus流动树脂及Fuji IX玻璃离子在牙颈部楔状缺损修复治疗中的应用效果。方法回顾性分析2020年1月至2021年12月抚州市临川区人民医院收治的150例(460颗患牙)牙颈部楔状缺损患者的临床资料,按照修复材料的不同分为FUJI组(n=49,152颗患牙)、Z350组(n=51,155颗患牙)及Beautiful组(n=50,153颗患牙)。FUJI组采用FUJI IX玻璃离子水门汀修复,Z350组予以Filter TMZ350 XT流动树脂修复,Beautiful组使用Beautiful Flow Plus流动树脂修复。比较3组治疗6、12个月后的修复成功率、微渗漏程度、边缘缝隙宽度。结果3组治疗6个月后修复成功率比较差异无统计学意义;3组治疗12个月后修复成功率比较差异有统计学意义(P<0.05),进一步两两比较差异均无统计学意义。治疗6、12个月后,3组微渗漏程度、边缘缝隙宽度比较差异均有统计学意义(P<0.05),其中Z350组、Beautiful组微渗漏程度均优于FUJI组,边缘缝隙宽度均小于FUJI组,差异有统计学意义(P<0.05),而Beautiful组与Z350组微渗漏程度、边缘缝隙宽度比较差异无统计学意义。结论牙颈部楔状缺损应用Filter TMZ350 XT、Beautiful Flow Plus流动树脂较FUJI IX玻璃离子水门汀具有一定优势,不仅远期修复成功率高,微渗漏程度更轻,且边缘缝隙宽度更小。
邓运龚文婷周强
关键词:牙颈部楔状缺损流动树脂玻璃离子
Transcriptomic analysis identifies the neuropeptide cortistatin (CORT) as an inhibitor of temozolomide (TMZ) resistance by suppressing the NF-kB-MGMT signaling axis in human glioma
2024年
Glioma is a common tumor originating in the brain that has a high mortality rate.Temozolomide(TMZ)is the first-line treatment for high-grade gliomas.However,a large pro-portion of gliomas are resistant to TMZ,posing a great challenge to their treatment.In the study,the specific functions and mechanism(s)by which cortistatin(CORT)regulates TMZ resis-tance and glioma progression were evaluated.The decreased expression of CoRT was detected in glioma tissues,and highly expressed CORT was associated with a better survival rate in pa-tients with glioma.CORT overexpression notably decreased the capacity of glioma cells to pro-liferate and migrate in vitro and to form tumors in vivo.CORT overexpression also markedly suppressed the viability and enhanced the apoptosis of TMZ-resistant U251 cells by regulating MGMT,p21,and Puma expression.Importantly,CORT overexpression reduced the resistance of gliomas to TMZ in vivo.CORT expression Was negatively correlated with MGMT expression in both glioma tissues and cells,and it was found that CORT inhibited NF-kB pathway activation in glioma cells,thereby inhibiting MGMT expression.In conclusion,CORT regulates glioma cell growth,migration,apoptosis,and TMZ resistance by weakening the activity of NF-kB/p65 and thereby regulating MGMT expression.The CORT/NF-kB/MGMT axis might be regarded as a molecular mechanism contributing to the resistance of glioma to TMZ.Our data also suggest that CORT regulates the viability and metastatic potential of glioma cells,independent of its effects on TMZ resistance,providing evidence of novel therapeutic targets for glioma that should be evaluated infurther studies.
Zongze HeBo PengQi WangJie TianPing LiuJie FengYiwei LiaoLongyi ChenPing JiaJian Tang
关键词:CORTISTATINMGMTTEMOZOLOMIDE
选择性MGMT多肽在胶质瘤中模拟TMZ耐药性的研究
研究背景:胶质母细胞瘤(Glioblastoma,GBM)是最常见的中枢神经系统原发性恶性肿瘤。替莫唑胺(Temozolomide,TMZ)是GBM患者的一线化疗药物,然而部分患者对TMZ的治疗具有耐药性,其主要原因是O...
吴玥
关键词:胶质瘤TMZMGMT肿瘤耐药多肽

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