搜索到2891篇“ PROTEINURIA“的相关文章
Post-streptococcal acute glomerulonephritis in children:Association between proteinuria levels and renal outcomes
2025年
BACKGROUND Post-streptococcal acute glomerular nephritis(PSAGN)is mostly a benign condition.The usual sequelae of PSAGN include hypertension,its complications,and acute kidney injury.Severe PSAGN is associated with significant long-term morbidity,and histological abnormalities such as crescentic glomerulonephritis are infrequently reported.PSAGN has also been linked to late-onset chronic kidney disease in some populations due to high levels of proteinuria.METHODS This prospective observational study was conducted at Lady Ridgeway Hospital(Colombo,Sri Lanka)over 15 months.Children with PSAGN were enrolled based on clinical and laboratory criteria.Persistent proteinuria≥2+for 2 weeks and serum creatinine>100μmol/L warranted renal biopsy,assessed via light microscopy and immunofluorescence.Normalization of complement 3(C3)within 6 to 8 weeks was required for inclusion.Data on clinical features,urine protein levels,and renal function were collected from patient records,and potential associations were analysed using Statistical Package for the Social Sciences and R language for statistical computing.Ethical approval was obtained from the Ethical Review Committee,Lady Ridgeway Hospital for Children(Ref No:LRH/ERC/2021/60).RESULTS Forty-four patients were recruited.There were 27(61.4%)male patients and 17(38.6%)female patients.Thirty-seven(84%)of them were above 5 years of age.Twenty(45%)patients had a history of skin sepsis,and eighteen(41%)had a history of throat infection.Among patients with proteinuria≥2+,53%had serum creatinine>100µmol/L,while among those with proteinuria<2+,7%had serum creatinine>100µmol/L.The association of high-degree proteinuria with elevated serum creatinine was significant(χ²=7.8,P=0.005)in PSAGN.The odds ratio of the logistic regression model was 1.049(95%confidence interval:1.003-1.098),indicating a positive direction with statistically significant association(P=0.037).There was no significant association between proteinuria and the degree of hypertension or estimated creatinine cl
Randula RanawakaKavinda DayasiriUdara SandakelumDulani NelsonManoji Gamage
关键词:PROTEINURIA
Analysis on clinicopathology and prognosis of primary IgA nephropathy in children with massive proteinuria.
2024年
Objective To investigate the clinicopathological features and the prognosis of IgA nephropathy (IgAN) in children with massive proteinuria.Methods It was a retrospective cohort study.Clinical data of IgAN children with massive proteinuria admitted to the Department of Nephrology,Children's Hospital Affiliated to Capital Institute of Pediatrics from January 2008 to December 2021 were retrospectively analyzed.
夏华
关键词:PROTEINURIAPROGNOSIS
基于数据挖掘技术的糖尿病肾病微量蛋白尿期与临床蛋白尿期证候比较研究
2024年
[目的]分析糖尿病肾病(DKD)相关文献,运用数据挖掘技术,比较微量蛋白尿期与临床蛋白尿期中医证候特点,以期为临床规范分期治疗DKD提供新思路。[方法]检索中国知网(CNKI)、万方数据知识服务平台和维普中文科技期刊数据库自2014年1月1日—2023年12月31日收录的相关文献,筛选符合纳入标准的文献,进行证候和症状的提取、名称规范及拆分。建立数据库,采用统计学软件对DKD的微量蛋白尿期与临床蛋白尿期相关证候进行频数统计和聚类分析。[结果]共检索文献3506篇,最终纳入文献79篇。证候方面微量蛋白尿期以气阴两虚、血瘀证、湿热证、阴阳两虚和阴虚燥热最为常见;临床蛋白尿期以气阴两虚、血瘀证、阴阳两虚、湿热证和痰湿证最为常见。症状方面,微量蛋白尿期常见症状为倦怠乏力、口渴多饮、口干咽燥、肢体麻木、视物模糊、夜尿频多、腰膝酸软、头晕目眩、失眠多梦、肢体疼痛;临床蛋白尿期常见症状为倦怠乏力、肢体麻木、水肿、视物模糊、腰膝酸软、口干咽燥、口渴多饮、头晕目眩、少气懒言、尿浊。[结论]随着病情进展,DKD的临床蛋白尿期相比于微量蛋白尿期,证候种类更加复杂多样,阳虚相关证候比例显著上升。
许艳超郑曙琴
关键词:糖尿病肾病数据挖掘中医证候
Clinical Observation on the Treatment of Diabetic Kidney Disease with Damp-heat Stasis Syndrome in Clinical Proteinuria Stage by Kunkui Kidney Preserving Paste
2024年
[Objectives]To evaluate the clinical efficacy and safety of Kunkui Kidney Preserving Paste in the treatment of diabetic kidney disease(DKD)patients with damp-heat stasis syndrome in the clinical proteinuria stage.[Methods]Retrospective analysis was made on 30 patients with DKD who were diagnosed with damp-heat stasis syndrome in the clinical proteinuria stage from March 2021 to March 2023 in Jiangsu Province Hospital of Chinese Medicine,and who took Kunkui Kidney Preserving Paste continuously for six months.The urinary albumin/creatinine ratio(UACR),urinary complement C3,and urea nitrogen(BUN)of DKD patients before and after treatment were compared,and estimated glomerular filtration rate(eGFR),blood creatinine(Scr),and cystatin C(CysC)were estimated,and the therapeutic effects on renal function and urinary protein were evaluated.[Results]After treatment,UACR significantly decreased(P<0.01),and urinary complement C3 and Scr decreased(P<0.05),while other indicators showed no significant statistical difference(P>0.05).In terms of evaluating the efficacy of urinary protein therapy,8 cases showed recent relief;8 cases showed significant effect;9 cases were effective,and 5 cases were invalid after treatment,with a total effective rate of 83.33%.In terms of renal function efficacy evaluation,8 cases showed significant effect;4 cases were effective;11 cases were stable,and 7 cases were invalid,with a total effective rate of 76.67%.In the safety evaluation,there were no obvious adverse reactions.[Conclusions]The Kunkui Kidney Preserving Past has significant clinical efficacy and safety in treating DKD patients with damp-heat stasis syndrome in the clinical proteinuria period.It has significant advantages in reducing urinary protein and protecting renal function,which is worthy of clinical promotion.
Ying TANQiling ZHANGJuan CHENXu YUQianhua YANJiangyi YU
关键词:PROTEINURIA
选择性尿蛋白指数临床应用的前景及挑战
2024年
肾小球滤过膜由于存在孔径屏障和电荷屏障,对血浆蛋白质有选择滤过作用。选择性尿蛋白指数(selectivity proteinuria index,SPI)可通过比较血浆中不同分子量大小的蛋白质的肾脏清除率来反映肾小球滤过膜的损伤程度及活跃肾单位整体通透性的改变,不但操作简便、适用于有肾活检禁忌证的患者和无肾活检条件的地区,还可以弥补肾活检只获取局部组织的不足。改善全球肾脏病预后组织膜性肾病指南提出SPI可作为危险分层、启动和确定治疗方案的临床指标之一。然而,SPI也具有公式不统一、特异性不高和干扰因素多等局限性。因此,联合其他指标共同指导临床工作具有重要意义。本文就SPI原理、计算方法、临床应用价值及面临挑战进行综述。
陈启亮戴兵
关键词:慢性肾脏病肾小球滤过膜
贝伐珠单抗致蛋白尿的潜在危险因素及保护因素分析
2024年
目的:回顾性分析贝伐珠单抗所致蛋白尿潜在的危险因素及保护因素,延缓蛋白尿进展,减少用药后严重肾脏损害及其他致命性不良反应。方法:选取2021年1月至2022年12月于北京大学人民医院接受安维汀(贝伐珠单抗注射液)治疗的住院患者电子病历共331份,其中蛋白尿阳性病历116份,阴性病历215份。应用SPSS 27.0软件进行统计分析,确定蛋白尿相关危险因素,对既往高血压及糖尿病患者潜在的保护因素进行分析。结果:331例患者中116例出现蛋白尿阳性,总发生率为35.05%,其中2级及以上蛋白尿发生率为13.29%。多因素logistic回归分析显示尿素氮基值、肾脏病史、用药周期及联合使用表皮生长因子-酪氨酸酶抑制剂(EGFR-TKI)与蛋白尿发生呈正相关(P<0.05),是发生蛋白尿的独立危险因素;非肾素-血管紧张素-醛固酮系统抑制剂(非RAAS抑制剂)、非钠-葡萄糖共同转运蛋白2抑制剂(非SGLT2i)的使用与发生蛋白尿呈正相关(P<0.05),是既往高血压、糖尿病患者发生蛋白尿的危险因素;尿素氮基值与发生蛋白尿的严重程度具有统计学意义(P<0.05);RAAS抑制剂与钙离子拮抗剂(CCB)联合使用与蛋白尿的发生呈负相关(β=-2.065,P<0.05),是既往高血压患者的保护因素。结论:贝伐珠单抗所致蛋白尿的发生率较高,在临床使用时应对患者基线尿素水平、既往肾脏疾病、用药周期、联合使用EGFR-TKI给予关注,控制好危险因素可以降低贝伐珠单抗所致蛋白尿的严重程度;对于既往高血压患者,应早期规范RAAS抑制剂与CCB联合用药以降低贝伐珠单抗所致蛋白尿的发生。
谷莹莹谷莹莹刘一黄琳任晓蕾
关键词:抗血管生成蛋白尿
胡晓梅治疗紫癜性肾炎蛋白尿经验
2024年
紫癜性肾炎蛋白尿病因病机主要包括肺受风邪、肺病传肾、阳亢阴弱、火热灼津,或病情迁延,久病及肾,最终导致肾虚血瘀。以肾为关键病位,以参芪地黄汤为主方,以补肾气、填肾精为基础治则,配伍祛风散邪、活血化瘀、利湿泻浊之品,疏散表邪,搜剔肾风,清利肾络,使败精去而精微生,恢复肾脏封藏之职,减轻患者蛋白尿水平。
牛继聪胡晓梅李雨蒙张梅吕妍
关键词:紫癜性肾炎蛋白尿参芪地黄汤肾虚血瘀
基于玄府理论探讨风药治疗蛋白尿的内涵
2024年
蛋白尿是肾脏疾病的常见临床表现,西医对蛋白尿的治疗以控制原发病为主,中医药在减轻或消除蛋白尿方面优势明显,且风药的运用独树一帜,但目前中医界对治疗蛋白尿的探讨多局限于单一疾病。玄府理论体现了中医学的微观视角,肾小球滤过膜、肾小管与玄府有共通之处,可视为肾之玄府之一。风邪侵袭是肾性蛋白尿的诱因,即风性开泄,循经入肾,使肾失封藏,精微外泄。玄府理论可为风邪诱发肾性蛋白尿的病理过程提供中医学微观视角。开玄启闭,需用风药,风药身兼数用,可开玄利水、畅玄活血,需寒温相伍、开补并施。
宋丹萍柳红芳陈佳慧李婷武怡平程发峰王庆国
关键词:异病同治玄府理论蛋白尿风药
曹式丽从毒论治蛋白尿经验被引量:1
2024年
蛋白尿属本虚标实、虚实错杂之证,本虚以肾虚为主,与肺脾肝相关,标实涉及风、湿、热、瘀、浊、毒等。肺脾肾三脏亏虚致三焦不利,水道不通,湿热浊瘀之邪郁而不化,渐变为毒,邪气积于体内,气血津液运行失常,导致脏腑不得濡养,加重脏腑亏虚,毒邪蓄积体内,导致肾体损伤,功能日渐衰退,难以恢复,形成蛋白尿。毒邪生成,肾脏损伤由可逆性变为不可逆性,且毒邪的生成和致病是循序渐进、逐量累积的,贯穿于蛋白尿全程。故在治疗蛋白尿时应注重“解毒”法的应用,需明辨三焦毒邪,随证选药,扶正解毒,标本兼治。肾络细窄,惟虫药之走窜方可直达脏腑,虫药有搜风剔络、解毒散结、益肾固本之功,配伍通络药物以解毒通络,络通则排毒有道,毒邪自解,诸症减轻。
申森杜雨芃林燕
关键词:蛋白尿慢性肾脏病从毒论治
中医药治疗蛋白尿研究文献可视化分析被引量:1
2024年
目的 基于VOSviewer和CiteSpace分析中医药治疗蛋白尿相关文献,探讨该领域研究热点和发展趋势。方法 检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)收录的2012年1月1日-2022年12月31日中医药治疗蛋白尿研究文献,采用NoteExpress3.7.0去重及人工筛选,采用Excel2021绘制发文趋势折线图及来源期刊柱形图,利用VOSviewer1.6.19绘制作者合作网络及关键词共现图谱,CiteSpace6.2.R2构建关键词聚类图、时间线图和突现分析图。结果 共纳入文献427篇,发文量基本稳定,总体呈下降趋势。来源期刊125种,研究机构229家,核心作者86位;机构类型主要为中医药高校及其附属医院;作者合作网络形成以何立群、米秀华、王怡、王立范等为核心的研究团队。突现词分析中突现强度最大的关键词为“脾肾气虚”,突现时间最长的关键词为“中医辨证”和“肾功能”。结论 中医药治疗蛋白尿研究领域作者和研究团队合作有待加强,研究机构类型较单一,应进一步发展多中心、高质量的多元化融合研究。研究热点主要集中在辨证论治、经验探讨和观察指标等方面,今后应加强对名老中医经验的挖掘和系统深入研究,开展中医药作用机制研究,推动循证医学及数据挖掘等研究方法的应用。
梁芷艺游德森张坪林碧莹
关键词:中医药蛋白尿可视化分析CITESPACE

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