[Objective] This study was to establish an optimized model for the allocation of agricultural fertilizer resources in Southern Xinjiang from the perspective of sustainable development.[Method] An optimized model for the allocation of agricultural fertilizer resources was established based on their allocation structure.Combined with the actual agricultural production in Aksu areas of Southern Xinjiang,by establishing a rational evaluation index system,under the premise of considering the planting area constraints,the total water resources constraints and the security constraints of food production,we established the empirical optimal allocation model of the regional agricultural fertilizer resources in Aksu area of Southern Xinjiang.Moreover,we solved the model by using the search algorithm of computer and lingo programming.[Result] The increased economic benefit was near to 1.8 billion Yuan by adopting the optimal allocation methods,with a relative increment of about 34.4%.[Conclusion] Our results provided theoretical basis for achieving the sustainable development of agricultural economy in Southern Xinjiang.