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刘文利

作品数:2 被引量:20H指数:2
供职机构:天津大学化工学院更多>>
发文基金:天津市自然科学基金国家自然科学基金更多>>
相关领域:医药卫生更多>>

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HPLC determination of Nimodipine in plasma with an improved sample refining method and its application in pharmacokinetic studies被引量:2
2016年
In order to prepare samples for HPLC analysis with maximum drug recovery and impurity elimination, a revised method for the extraction and purification of a target substance from plasma was developed and applied in a pharmacokinetic study with Nimodipine as a model drug. After protein precipitation of a plasma sample using pure methanol and evaporation of the supernatant to dryness, methanol of various concentrations from 10% to 100% were used to dissolve the remaining residues with the goal of maximizing drug recovery and impurity elimination. Through rigorous screening with HPLC peaks from residual impurity and recovered drug as the criteria, a methanol concentration of 30% was chosen. The standard curve was linear (r2〉 0.999) over the range of 2-160 ng/mL with a limit of quantification (LOQ) of 2 ng/mL. Intra- and inter-day precision values were below 15%, and the accuracy ranged from -1.70% to 5.88% at all three quality control (QC) levels. The wavelength of maximum absorption was 238 nm, and a smaller LOQ value of 2 ng/mL was achieved compared with the reported method. The revised method was successfully applied in a pharmacokinetic study of Nimodipine in rats and sample preparations of lidocaine hydrochloride.
王晓娜陈瑞莲刘文利龚俊波王永莉魏振平
关键词:NIMODIPINEHPLC
新型固体分散体技术改善水难溶药物溶解度的研究进展被引量:18
2016年
通过改善水难溶药物的溶解度来提高其溶出速率以及口服后的吸收和生物利用度,是开发此类药物的口服制剂所面临的一大挑战。相对于其他制剂技术,用固体分散技术改善水难溶药物的溶解度,简便易行而更有优势也更受到关注。在简要介绍固体分散体的特点基础上,笔者重点对近年来固体分散体制备中所用的新型载体材料和制备方法进行综述。介绍了两亲性聚合物:聚乙二醇羟基硬脂酸酯、聚乙烯己内酰胺-聚醋酸乙烯酯-聚乙二醇接枝共聚物、2-甲基丙烯酰乙氧基磷酰胆碱单体与甲基丙烯酸丁酯单体嵌段共聚物;还有无机材料:硅酸铝镁、介孔二氧化硅微粒和介孔碳酸镁,以及新型制备方法:超临界流体技术、高速静电纺丝和微环境pH修饰技术。
刘文利魏振平
关键词:固体分散体溶解度体外溶出度
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