丹参酮IIA,也称为TanIIA,在生物体内代谢过程中扮演着多重角色,其产物能够影响多种生物化学反应。这些反应中,TanIIA有时作为辅酶参与,有时则可能促进或干扰这些反应过程,从而展现出多样的药理特性。尽管在脊髓损伤等神经系统疾病的治疗中,TanIIA已经显示出了一定的疗效,但其具体的作用机制尚未完全阐明。基于现有的研究成果,我们推测TanIIA可能通过多种药理途径,包括抗炎、抗氧化、抗细胞凋亡以及保护血管,来促进脊髓损伤后的神经细胞存活和修复。Tanshinone IIA, also known as TanIIA, plays multiple roles in the metabolic process of living organisms, and its products can affect a variety of biochemical reactions. In these reactions, TanIIA is sometimes involved as a coenzyme, and sometimes it may facilitate or interfere with these reaction processes, thus exhibiting diverse pharmacological properties. Although TanIIA has shown some efficacy in the treatment of neurological diseases such as spinal cord injury, its specific mechanism of action has not been fully elucidated. Based on the existing research results, we speculate that TanIIA may promote the survival and repair of nerve cells after spinal cord injury through multiple pharmacological pathways, including anti-inflammatory, antioxidant, anti-apoptosis, and vascular protection.
丹参酮IIA (Tanshinone IIA, TanIIA)是从中药丹参中提取的主要有效成分之一,研究表明其在抗炎、抗氧化、抗肿瘤、心脏保护及神经系统保护方面具有显著的药理活性。本文采用文献计量学的方法,对国内外有关丹参酮IIA的研究进行分析,发现丹参酮IIA的研究是基于2000年至2024年间发表的13,681篇有关丹参酮IIA的文献的计量学分析;该领域发表研究论文最多的国家是中国,美国和澳大利亚,而发表论文最多的机构为中国医科大学,中国科学院和中山大学。丹参酮IIA在心血管疾病和神经系统疾病中的研究文献占比最高,研究类型主要以应用基础研究,临床研究和技术开发为主,出现频率最多的关键词为凋亡,表达,激活,氧化应激,炎症反应等,体现了其在这些领域的研究热度和临床应用价值。丹参酮IIA作为一种具有多重药理活性的中药成分,显示出广泛的临床应用前景,而当前研究的局限性和挑战需要我们在未来的研究中予以重视,通过多学科合作和创新研究方法,共同推动丹参酮IIA在疾病治疗中的进一步应用与发展。Tanshinone IIA (TanIIA) is one of the main active ingredients extracted from the traditional Chinese medicine Danshen, and studies have shown that it has significant pharmacological activities in anti-inflammatory, antioxidant, anti-tumor, cardioprotective and nervous system protection. In this paper, bibliometric methods were used to analyze the studies on tanshinone IIA at home and abroad, and found that the research on tanshinone IIA was based on quantitative analysis of 13,681 articles on tanshinone IIA published between 2000 and 2024. The countries with the most published research papers in this field are China, United States and Australia, while the institutions with the most published papers are China Medical University, Chinese Academy of Sciences and Sun Yat-sen University. Tanshinone IIA has the highest proportion of research literature in car
目的:通过查阅预防性使用万古霉素粉末手术比较的文献,对该方法在脊柱手术后降低感染率的效果做出系统评价,为以后的临床工作提供依据。方法:通过Pubmed,Medline,Elseveir,万方,CNKI等数据库,以“vancomycin”,“local/intraoperative/topical/intra-wound”,“spine/spinal/lumbar/cervical/thoracolumbar surgery”,“infection”,“SSI”,“脊柱”,“腰椎”,“颈椎”,“手术”,“万古霉素”,“感染”等关键词查找相关术中预防性应用万古霉素粉末对术后感染发生率影响方面的病例对照研究论文,并利用Revman5.3荟萃分析软件比较文献中总体感染率,并按不同亚组分析是否应用万古霉素对不同部位、不同类型的脊柱手术的感染率的影响。结果:共查出论文1713篇,其中病例对照试验有38篇,最后筛选出符合要求的文献25篇;有25个研究比较了预防性使用万古霉素粉末对脊柱手术后感染率的影响。总病例16,688例,其中预防性使用万古霉素组7048例,对照组9640例。其荟萃分析结果提示术中预防性使用万古霉素粉末后术后出现感染的可能性为不使用万古霉素时的0.38倍,二者之间的差异有显著性(P Objective: To systematically evaluate the effect of this method in reducing the infection rate after spinal surgery by reviewing the comparative literature of prophylactic vancomycin powder surgery, so as to provide a basis for future clinical work. Methods: Pubmed, Medline, Elseveir, Wanfang, CNKI and other databases, with the following methods: “vancomycin”, “local/intraoperative/topical/intra-wound”, “spine/spinal/lumbar/cervical/thoracolumbar surgery”, “infection”, “SSI”, “spine”, “lumbar spine”, “cervical spine”, “surgery”, “vancomycin”, “infection” and other keywords were used to find case-control research papers on the effect of intraoperative prophylactic vancomycin powder on the incidence of postoperative infection, and the Revman5.3 meta-
