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蛇床子中3种逆转肿瘤细胞多药耐药活性香豆素被引量：31: 2003年; 目的　从蛇床子 Cnidium monnier中分离逆转肿瘤细胞多药耐药活性成分。方法　用生物活性跟踪法 ,经硅胶柱层析、RP- HPL C等。结果　分离得到 3种活性成分 ,分别为欧芹属素乙 (im peratorin) ,爱得尔庭 (edultin) ,9-异丁酰氧基 - O-乙酰基哥伦比亚苷元 (3′- isobutyryloxy- O- acetyl columbionetin)。结论　体外实验表明 3种化合物对耐药的肿瘤细胞 KBV2 0 0具有明显的逆转作用。; 张庆林赵精华毕建进曹菊荣宋京吴祖泽; 关键词：蛇床子香豆素多药耐药 KBV200

hMIR表达载体转入CHO细胞系作为药物靶点的初步研究: 作为新药发现和药理研究的最重要靶标,G蛋白偶联受体(G protein coupled receptor, GPCR)在创新药物研发中具有不可替代的地位。人毒蕈碱型胆碱能受体Ⅰ型(human muscarinic rec...; 刘永学王琼赵精华路晓钦高月谭洪玲高沛永; 关键词：CHO细胞孤儿G蛋白偶联受体靶点; 文献传递

高效液相色谱法分析小鼠血浆中贝母乙素及其药代动力学研究被引量：7: 2000年; 目的　研究小鼠腹腔注射贝母乙素的药代动力学。方法　反相液相色谱法定量分析。血浆样品经乙醚提取后 ,柱前用2 ,4 二硝基苯肼衍生 ,分析色谱柱 :HypersilC18,流动相 :乙腈乙酸铵 (0 .1mol·L-1,pH =5 ) (39∶6 1) ,UV375nm检测。结果　在0 .114～ 1.2 6 μg·ml-1区间 ,标准曲线线性方程为Y =0 .12 6X - 0 .0 0 13,相关系数r=0 .992 3,平均日间、日内精密度RSD分别为5 .85 %和 5 .30 %。平均相对回收率为 96 .5 %。结论　小鼠注射贝母乙素 (1.5mg·kg-1)的血药浓度时间曲线符合一室开放模型 ,t1/ 2 为 0 .84h ,cmax为 0 .87μg·ml-1,tmax为 0 .15h。; 张庆林王爱芹宋京李军林曹菊荣赵精华唐仲雄吴祖泽; 关键词：高效液相色谱药代动力学

Screening of Common Traditional Chinese Drugs for Reversing Multidrug Resistance of KBV200 In Vitro被引量：2: 2002年; The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$; 张庆林赵精华曹菊荣宋京毕建进王小娜龚萍吴祖泽; 关键词：SCREENING

Screening of Common Traditional Chinese Drugs for Reversing Multidrug Resistance of KBV200 In Vitro被引量：4: 2002年; The ethanolic extracts of 100 common traditional Chinese drugs, which are widely used in many prescriptions in treatment of cancer in China, were screened for MDR of KBV200 cell line in vitro with MTT method. The result showed 9 extracts having MDR reversal activity. They were the extracts of Fructus Lagenariae Sicerariae, Radix Glycyrrhizae, Poria, Herba Andrographitis, Radix Sophorae Tonkinensis, Caulis Mahoniae, Folium Artemisiae Argyi, Rhizoma Curcumae, Fructus Cnidii. Other 5 extracts showed cytotoxic on KBV200 cell line. $$$$; 张庆林赵精华曹菊荣宋京毕建进王小娜龚萍吴祖泽; 关键词：SCREENING; 全文增补中

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