Objective To compare the therapeutic effect between needling combined with moxibustion at Baihui (百会 GV 20) and conventional needling for treatment of insomnia, and to verify the synergy of moxibustion at Baihui (百会 GV 20) on insomnia. Methods Two hundreds and seven cases of insomnia patients were randomly divided into observation group and control group. The conventional needling combined with moxibustion at Baihui (百会 GV 20) was applied in observation group, and the conventional needling was employed in control group, once a day, and for 5 consecutive days per week, 4 weeks as a course, and 1 course in total. Pittsburgh Sleep Quality Index (PSQI) Scale was adopted before and after the treatment, and the therapeutic effects of two groups as well as of asthenia and sthenia syndromes and among syndromes were observed and compared in observation group. Results After treatment, PSQI scores of both groups significantly improved (both P〈0.05), and the score of observation group was superior to that of control group (P〈0.05); after 1 course, the total effective rate in observation group was 88.0% (88/100), superior to 74.5% (73/98) in control group (P〈0.05); in observation group, the total effective rate was 92.4% (61/66) of asthenia syndrome, superior to that of 79.4% (27/34) of sthenia syndrome (P〈0.05). Conclusion Needling combined with moxibustion at Baihui (百会 GV 20) has marked therapeutic effect on insomnia, with better effect on prolonging the time of sleep, improving the sleep quality than that of single needling. And the therapeutic effect on asthenia syndrome was superior to that of sthenia syndrome.