Objective: To study the therapeutic effects of Morita therapy on hypochondriac neurosis. Methods: 50 patients diagnosed as hypochondriac neurosis according to CCMD-2-R were treated with stage occupational life experience therapy for 12 to 14 weeks. The therapeutic effects were assessed by MMPI before and after treatment. A follow-up assessment was also conducted 6 months after treatment. Results: The highest scores of the patients with hypochondriac neurosis were Hs, D, Hy, Pt, showing the 1-2-3-7 MMPI profile. Scale scores on Pd, Pa, Sc were higher than norms. The elevated MMPI scale scores showed significant decrease after treatment, especially for scales 1,2,3,7. The treatment response rate was 78% and the relapse rate after 6 months was 13.95%.Conclusion: Morita therapy was shown to achieve satisfactory therapeutic effects on hypochondriac neurosis.