Objective: To develop the Evaluation Questionnaire of College Students’ Mental Health, and to explore its factor-structure. Methods: The Evaluation Questionnaire of College Students’ Mental Health was developed on the basis of an open and semi-structure questionnaire survey and literature review. The factor structure of the questionnaire was examined by exploratory and confirmatory factor analysis. Results: A six-factor model was obtained by exploratory factor analysis. The confirmatory factory analysis showed that the fit indexes for GFI, AGFI, NNFI, and CFI were 0.65, 0.68, 0.70, and 0.71 respectively (χ2/df = 2.23). Conclusion:The factor structure is fit to describe the characteristics of the mental health of the college students.