This paper discusses the principle and procedures of the second-generation wavelet transform and its application to the denoising of seismic data. Based on lifting steps, it is a flexible wavelet construction method using linear and nonlinear spatial prediction and operators to implement the wavelet transform and to make it reversible. The lifting scheme transform -includes three steps: split, predict, and update. Deslauriers-Dubuc (4, 2) wavelet transforms are used to process both synthetic and real data in our second-generation wavelet transform. The processing results show that random noise is effectively suppressed and the signal to noise ratio improves remarkably. The lifting wavelet transform is an efficient algorithm.