目的 研究可溶性b7-h3分子(sb7-h3)在菌血症及慢性乙型肝炎(chb)患者血清中的水平及其意义.方法 用elisa法分别检测50例菌血症患者、78例chb患者和50例健康人血清中的sb7-h3水平,分析其与白细胞、中性粒细胞、淋巴细胞和单核细胞量变的相关性.结果 菌血症患者血清中sb7-h13的浓度为(50.69±26.43)μg/l,显著高于健康人群的(16.89±5.15)μg/l(p＜0.01),而chb患者血清中sb7-h3的浓度为(18.07 ±7.28)μg/l,与健康人群相比差异无统计学意义(p＞0.05);菌血症患者血清中sb7-143的水平与外周血白细胞和中性粒细胞计数呈显著正相关.结论 sb7-h3具有潜在的临床应用前景,可作为协助诊断菌血症的一项新参数.
abstract：
objective to investigate the seruln levels of solubl b7-h3(sb7-h3)in patients withbacteremia and in those with chronic hepatitis b(chb),and its clinical significance.methods serumlevels of sb7-h3 from 50 bacteremia patients,78 chb patients and 50 healthy individuals wero detected byeusa,and its correlations with the quantities of leucocytes,neutrophils,lymphocytes and monocytes wereanalyzed.results the average level of sb7-h3 in serum of bacteremia patients was(50.69±26.43)μg/ml which was higher than that of healthy group(p＜0.01);serum sb7-h3 level of patients with chb was(18.07±7.28)μg/ml,and it had no significant difference compared with that in the healthy group(p＞0.05).besides,positive correlations between the scrum sb7-h3 level in and the quantities of leucocytesand granulocytes were observed in bacteremia patients.conclusions it suggests that sb7-h3 misht bepotentially used as a new parameter to improve the clinical diagnosis of bacteremia.
