Objective:To investigate the relationship between C-reactive protein and psychosomatic symptoms in patients with type 2 diabetes. Methods:60 patients with diabetes and 30 normal controls were assessed with SCL-90 and the blood concention of C-reactive protein was measured. Results:The factor scores of somatization ,anxiety and social interaction sensitivity in high CRP group were significantly higher than those of normal CRP group. Conclusion: CRP was correlated with some psychosomatic symptoms in patients with type 2 diabetes.