Objective:To explore the plasma catecholamines (CAs) concentration of postnatal depression and to analyze the relationships between postnatal depression and CAs level. Methods:Using high performance liquid chromatography (HPLC) to measure the subjects’ plasma noradrenaline (NE)?adrenaline (E) and dopamine (DA) concentration. The postnatal depression group was compared with depression, ante partum and normal group.Results: NE level of plasma in the depression group and the postnatal depression group were all higher than those of normal group P <0.05).E:there were no significant differences on E level of plasma between two groups. DA level of plasma in the postnatal depression group higher than that of normal group( P <0.01) but depression group and normal group had no significant difference ( P >0.05) .Conclusion:the plasma NE increase is relative to postnatal depression episode,the plasma DA may be relative to postnatal depression episode. The relationship between plasma and postnatal depression remains unclear.