Absorption refrigeration using R22 as refrigerant and organic solution as absorbent has been widely studied and has even found its application in some cases. But with the forthcoming phasing out date of R22, the research on alternative of R22 in absorption refrigeration is becoming more and more important. In this paper, the characteristics of the cycle using R134a+R32/DMF and R22/DMF respectively under different working conditions were calculated and analyzed. The comparison shows that the new working pair will not only avoid the depletion of the ozone, but also have a higher COP and refrigeration capacity.