[Objective]The aim was to discuss elimination mechanism and equilibrium model about complete linkage gene of panmixis based on fitness.[Method]A mathematical model that gsgenerational evalution of frequency of panmixis two pairs of complete linkage gene under difference fitness was built by using difference equations to study elimination mechanism and genetic equilibrium state of panncticcoinplete linkage gene.[Result]The panmixis is different from Hardy-Weinberg Equilibrium which reached the equilibrium just by one generation.A method that by using linear equation to calculate the frequency of four gametes and the fitnessed of panmixis was established after detormining is the fitness of 10 genotypes the necessary and sufficient condition of the panmixis to reach balance.[Conclusion]The method is valuable for reference on linkage disequilibrium and hitchhiking effect study.
