The hot deformation behavior of Ti-3.0Al-3.7Cr-2.0Fe-0.1B (TACFB) titanium alloy was investigated using a Gleeble-1500D thermal simulator in the temperature range of 800-950 °C, at constant strain rate from 0.01 s-1 to 10 s-1 and with height reduction of 70%. Flow stress and microstructure evolution during hot compression of TACFB alloy were investigated. The processing map of TACFB alloy was obtained. The results indicate that the hot deformation behavior of TACFB alloy is sensitive to the deformation temperature and strain rate. The peak flow stress decreases with increasing the test temperature and decreasing the strain rate. The constitutive relationship of TACFB alloy was obtained on the base of Arrhenius equations. When the strain rates are higher than 1.0 s-1, the dynamic recrystallization occurs, and the higher the strain rates are, the more the recrystallization is.