The four treatments of spraying water the control, spraying before bagging, spraying after bagging, spraying without bagging were conducted by spraying 38% of the mixed suspension agent of imidacloprid and buprofezin, and high performance liquid chromatography (HPLC) method was used to test the imidacloprid and buprofezin residues on mango. The results showed that in 0.05-0.5 mg/kg adding level, the average recovery rate of imidacloprid and buprofezin was 82.6-93.8%, and 101.4-104.2%, respectively, and the relative deviation (RSD) was 1.9-4.5%, 9.3-15.6%, respectively. The minimum detectable amounts of both imidacloprid and buprofezin on mango were 0.01 mg/kg. The half-life periods of imidacloprid under the treatments of spraying before bagging, spraying after bagging and spraying without bagging were 16.74, 6.38, and 8.10 d, respectively, and the half-life periods of buprofezin under the treatments of spraying before bagging and spraying without bagging were 9.72 and 9.23 d, respectively. The residual of buprofezin was low in the treatment of spraying after bagging, and the amount detected in the 3rd day had already below the detectable limit. Bagging treatment reduced the digestion rate of 2 kinds of pesticides in mango, and imidacloprid had strong systemic in mango.