在成年偏头痛患者中,约有四分之一存在卵圆孔未闭的情况,研究表明,因右向左的房间血液分流,PFO与偏头痛之间可能存在相关性。尽管PFO封堵术已取得广泛应用,但不同研究对于PFO伴偏头痛患者在封堵术后缓解有效率仍存在争议。为筛选出可能获益的患者群体,以提高PFO封堵术后偏头痛缓解有效率及评估术后疗效,偏头痛相关缓解指标的研究则显得尤为重要。本文旨在对卵圆孔未闭封堵术后偏头痛缓解指标的研究进展进行综述。In adult patients with migraines, approximately one-quarter are found to have a patent foramen ovale (PFO). Emerging studies suggest a potential association between PFO and migraines, which may be attributable to right-to-left shunting of blood between the atria. Although PFO closure procedures are routinely performed, the efficacy of these interventions in mitigating migraine symptoms remains a subject of ongoing debate. It is imperative to identify patient populations that may derive benefit from PFO closure and to evaluate the outcomes following such procedures. Consequently, research focused on migraine relief indicators is of paramount importance. This review aims to synthesize the current advancements in the investigation of indicators of migraine relief after closure of patent foramen ovale.
建立改良的体外培养大鼠脑皮质微血管内皮细胞缺氧模型．取1-5 d Wistar乳鼠脑皮质获得的脑微血管内皮细胞(BMEC)进行体外培养,缺氧组置入一个经改造的保鲜盒内,密闭并通入混合气体(95％N2和5％CO2)12 h, 检测缺氧细胞的形态结构、细胞死亡率及培养液中乳酸脱氢酶漏出量．结果显示缺氧BMEC形态结构损伤,细胞死亡率增加,细胞乳酸脱氢酶漏出量显著增加(p<0．01)．该模型可使脑血管内皮细胞受到损伤,证实该模型具有一定的可靠性,操作简便,可重复性强,为体外研究脑血管疾病提供帮助．
