The authers applicated "Neimadian point" acupuncture to orthopedic surgery of extremities and achieved excellent result. 60 cases of orthopedic operation of extremities were divided randomly into two groups: acupuncture analgesia and control groups. The sex, age and duration of operation of the two groups were basically same. The surgery was performed under rouotine druge anesthesia. The Neimadian points of both legs of the patients in the acupuncture analgesia group were acupunctured and stimulated electrically for 30 minites before drug anesthesia. The postoperative pain state was observed with blind method. According to the WHO formulated grading standards of pain, the postoperative pain were divided into 0,Ⅰ,Ⅱ,Ⅲ grades. The patients’ vital life signs, expression changes, and the administration and dosage of the analgesics were observed continuously for 24 hr after operation. Combining with the painful score records (performed by patients themselves) and according to NRS figure grading standards, the painful scores of each patient were evaluated. The results shown that the analgesic effect of acupuncture group was better significantly than that of control group(P<0.05). Under "Neimadian point" acupuncture anesthesia performing operation of extremities was successful, and our research data demonstrated that the level of plasma angiotensin Ⅱ during operation and after operation had no significant changes compared with preoperation. This shown that the blood pressure of patients was stable during and after operation. It also shown that plasma endorphin β level during and after operation was significantly higher than that of preoperation, suggesting an analgesic effect of "Neimadian point" acupuncture. Compared with drug analgesia, "Neimadian point" acupuncture analgesia has some advantages, such as no complex instrument needed, easy operation, low expenses, no side effects, easier to be accepted by patients, etc.