It is a fact that the near surface loess has magnetic susceptibility anomalies in oil and gas areas. Why these anomalies occur and whether they have any significant value for the exploration of oil and gas reservoirs are questions that geophysicists are mostly concerned about and study. We analyze the cause of the formation of surface loess susceptibility anomalies in oil and gas areas, process the observations of the susceptibility of loess samples taken from an oil and gas area in western China with proper mathematical methods, and determine the background value of loess susceptibility. These results are used to determine oil and gas prospect areas with a numeric evaluation factor based on the susceptibility anomalies. Actual oil wells have verified that using the susceptibility anomalies to indicate the location of oil and gas reservoirs is valid.