The dynamic interaction between the maglev vehicle and the three-span rigid frame bridge is discussed. With the consideration of magnetic force, the interaction model is developed. Numerical simulations are performed to study the dynamic characteristics of the bridge during vehicle movement along the bridge. The results show that a reasonable value of the linear stiffness ratio of columns to beams is between 2. 0 and 3.0. The dynamic responses of the bridge are aggravated with the decrease in bending rigidity and the increase in vehicle speed and the span ratio of the bridge. It is suggested that a definite way is to control impact coefficients and acceleration in the dynamic design of the bridge. It is unsuitable to adopt the moving load model and the moving mass model in the design. The proposed results can serve in the design of high-speed maglev three-span rigid frame bridges.