Based on the engineering background of the Jiangxinzhou Bridge in Nanjing, issues related to the spatial main saddle of the self-anchored suspension bridge are studied. The refinement finite element model is established by the secondary development technology based on the platform of the general finite element program, and a reasonable load pattern is used in its spatial structural analysis, by which its path of force transference and stress distribution are obtained. Matched with the spatial main cable, the tangency point correction method is also discussed. The results show that the lateral wall stress of the saddle groove is higher than the stress within the wall due to the role of lateral forces in the finished bridge state; the horizontal volume force of the main cable can generate a gradient distributed vertical extrusion pressure on the saddle clamping device and the main saddle body; the geometric nonlinear effect of the self- anchored suspension bridge cable system in the construction process is significant, which can be reflected in the spatial tangent point position of the main cable with the main saddle changes a lot from free cable to finished cable.