stick moxibustion on the "Baihui" and "Dazhui" of mice of aging model induced by D-galactose,and then hippocampus of mice in normal control group, modeling group and stick moxibustion groupwas gotton respectively, synaptosomal protein was extracted and analyzed by SDS -PAGE and Minorlayer scanning. The results showed that, in modeling group of D-galactose, changes of relative contentof eight types of protein in hippocampi were greater than 5 %, among them, 4 was up and 4 was down.Above 8 types of protein in stick moxibustion curing group, except for 36 KDa protein, other 7 types ofrelative content proteins changed compared with modeling group. Protein increased (or decreased) inmodeling group decreased (or increased) in curing group. It maybe suggest that stick moxibustion hasgood dual regulation to the disadvantageous effect of D- galactose on hippocampal synaptosomal proteins of