Objective To establish a warehouse on acupuncture-moxibution (acup-mox) methods to explore valuable laws about research and clinical application of acup-mox in a great number of literature by use of data mining technique and to promote acup-mox research and effective treatment of diseases. Methods According to the acup-mox literature information of different types, different subjects of the aeup-mox literature are determined and the relevant database is established. In the continuously enriched subject database, the data warehouse catering to multi-subjects and multi-dimensions is set up so as to provide a platform for wider application of aeup-mox literature information. Results Based on characteristics of the acup-mox literature, many subject databases, such as needling with filiform needle, moxibustion, etc., are established and clinical treatment laws of acup-mox are revealed by use of data mining method in the database established. Conclusion Establishment of the acup-mox literature warehouse provides a standard data expression model, rich attributes and relation between different literature information for study of aeup-mox literature by more effective techniques, and a rich and standard data basis for acup-mox researches.