The Cs0.1Cu0.2HXPVAs0.2Mo10Oy and Fe0.12HXPVAs0.3Mo11Oy catalysts were prepared by impregnation method and characterized by FT-IR and TPR.The propane oxidation on the catalysts were carried out in a continuous flow fixed-bed reactor.The result indicated that,under the conditions:V(N2)∶V(O2)∶V(C3H8)=2.2∶3.6∶1.2 θ=440℃,the catalysts performed in activity to a certain extent:over the catalyst of Cs0.1Cu0.2HXPVAs0.2Mo10Oy,the conversion for propane reach 72.92%,with a selectivity of 6.01% to acrylic acid and 2.91% to acetic acid;over Fe0.12HXPVAs0.3Mo11Oy catalyst,the conversion for propane was only 35.56%,but the selectivity for acrylic was as high as 12.15%,and acetic acid was 18.62%.The result showes that Cu could improve the conversion of propane,but could not inhibit the total oxidation product effectively,while Fe could enhance the selectivity for acrylic and acetic acid,but could not improve the conversion for propane.