ObjectiveKarst area is one of ecological fragile regions in China, where the economic and social development is lagged heavily. In recent years, with the constant development of the west regions, economy and society are developed rapidly and urbanization speed is accelerated. This study aims to investigate the spatial pattern and process of urbanization in karst area of Guiyang City, which has important significance for land management and urban planning in karst area. MethodBased on RS and GIS technologies, TM satellite images in 1986, 1995 and 2000 and CBERS-01 satellite image in 2006 were adopted to obtain the data of urban land utilization in Guiyang City in the four years. The spatial pattern and process of urbanization in Guiyang City were investigated using urbanization proportion index (UPI), urbanization intensity index (UII) and absolute expansion intensity (AEI). ResultThe urbanization process in Guiyang City was significant, exhibiting polygon-urbanization, line-urbanization and point-urbanization. From the perspective of spatial pattern, the urbanization in Guiyang City displayed the cluster development; from the perspective of urbanization process, the urbanization speed in some secondary central areas was higher than that of central areas. ConclusionThe spatial pattern and process of urbanization in karst area were unique and were mainly influenced by terrain, transportation, economy, society and so on.