[Objective] Long-term (over 18 years) fertilization experiments were con- ducted to study the responses of crop yields and soil fertility to long-term nutrient lacking at Zhengzhou in China. [Method] The present study consisted of five treat- ments: 1 CK (no fertilizer or manure), (2) NP (nitrogen and phosphorus fertilizer applied), 31 NK (nitrogen and potassium fertilizer applied), 4 PK (phosphorus and potassium fertilizer applied) and :5 NPK (nitrogen, phosphorus and potassium fertil- izer applied). [Result] Lacking of nitrogen or phosphorus led to a low yield; however, there was no significant difference in grain yields between the NP and NPK treat- ments which maintained a higher yield. Receiving no phosphorus, soil available phosphorus content declined to about 2.5 mg/kg. The concentration of soil ex- changeable potassium remained constant at a level of 60 mg/kg under the treat- ments without potassium fertilizer addition. Soil potassium spontaneous supply ca- pacity fluctuated around 100%.[Conclusion] In fluvo-aquic soil, nitrogen and phos- phorus were two key limiting factors to grain yields, biomass and yield component factors of wheat and maize, while potassium was not. However, potassium defi- ciency may occur in the future if there was still no potassium fertilizer applied.