The title compound（9S,13R,14S）-7,8-dehydro-4-（4＇-bromo-benzyloxy）-3,7-dime-thoxy-17-methyl-morphinan-6-one monohydrate（O-4-bromobenzylsinomenine） was synthesized by the reaction of（9S,13R,14S）-7,8-dehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one with 4-bromobenzyl alcohol.Its chemical structure was determined by X-ray single-crystal diffraction.The crystal belongs to the monoclinic system,space group P21 with a = 8.890（2）,b = 14.757（4）,c = 9.205（2） ,β = 91.577（4）°,C26H30BrNO5,Mr = 516.42,μ = 1.740 mm-1,V = 1207.2（5）3,Z = 2,Dc = 1.421 mg/m3,F（000） = 536,R = 0.0785 and wR = 0.1889.
Poly（L-lactide-co-caprolactone）（85-15）[P（LLA-CL）（85-15）] was synthesized from high purity L-lactide and e-caprolactone using tin octoate as initiator by ring-opening polymerization, and characterized by infrared spectrum and IH-NMR spectrum. The synthesized P（LLA-CL）（85-15） is a random copolymer. The influences of polymerization temperature, polymerization time, dosage of initiator and polymerization pressure on the weight average molecular weight and the polydispersity index of P（LLA-CL）（85-15） were investigated. The optimum preparation conditions of P（LLA-CL）（85-15） are： the polymerization pressure is less than 0.5 Pa, the polymerization temperature is 130 ~C, the n（M）/n（I） ratio is 8 000/1, and the polymerization time is 36 h. Under the condition, the weight-average molecular weight of prepared P（LLA-CL）（85-15） is 65.6x 104, and molecular weight distribution coefficient is 1.15.
Gas chromatography-mass spectrometry(GC-MS) and the chemometric resolution method(alternative moving window factor analysis,AMWFA) were used for comparative analysis of volatile constituents in herbal pair(HP) flos lonicerae-caulis lonicerae(FL-CL) and its single herbs.The temperature-programmed retention index(PTRI) was also employed for the identification of compounds.In total,44,39,and 50 volatile chemical components in volatile oil of FL,CL and HP FL-CL were separately determined qualitatively and quantitatively,accounting for 87.22%,94.54% and 90.08% total contents of volatile oil of FL,CL and HP FL-CL,respectively.The results show that there are 32 common volatile constituents between HP FL-CL and single herb FL,33 common volatile constituents between HP FL-CL and single herb CL,and 10 new constituents in the volatile oil of HP FL-CL.
The title compound （7R,8S,9S,12S）-13,14-dehydro-1-（4-fluorobenzyloxy）-N-methyl- 2,13-dimethoxy-12-hydroxymorphinane was synthesized by the reaction of O-4-bromobenzyl- sinomenine with lithium aluminum hydride. Its chemical structure was determined by X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P1 with Mr = 439.51, a = 7.7236（1）, b = 8.7282（1）, c = 9.9342（2） A, a = 81.176（1）, β = 67.43, γ= 64.577（1）°,μ = 0.76 mm^-1, V= 558.45（2） A3, Z = 1, Dc = 1.307 mg/m3, F（000） = 234 and T= 133 K.
