The effects of various reaction conditions on the preparation of polyalkylcyanoacrylate （PACA） nanoparticles are studied. The PACA nanoparticles with different crosslinking degrees and morphology are prepared. Addition of crosslinkers can not only adjust the particle size, but also change the morphology of PACA nanoparticles. Moreover, the loose network structure of the PACA nanoparticles with ＂core/shell-like＂ morloholozv is investizated by AFM and TEM in detail.
