Recurrent event data often arises in biomedical studies, and individuals within a cluster might not be independent. We propose a semiparametric additive rates model for clustered recurrent event data, wherein the covariates are assumed to add to the unspecified baseline rate. For the inference on the model parameters, estimating equation approaches are developed, and both large and finite sample properties of the proposed estimators are established.
This paper discusses efficient estimation for the additive hazards regression model when only bivariate current status data are available. Current status data occur in many fields including demographical studies and tumorigenicity experiments （Keiding, 1991; Sun, 2006） and several approaches have been proposed for the additive hazards model with univariate current status data （Linet M., 1998; Martinussen and Scheike, 2002）. For bivariate data, in addition to facing the same problems as those with univariate data, one needs to deal with the association or correlation between two related failure time variables of interest. For this, we employ the copula model and an efficient estimation procedure is developed for inference. Simulation studies are performed to evaluate the proposed estimates and suggest that the approach works well in practical situations. An illustrative example is provided.
TONG XingWei 1,,HU Tao 2 & SUN JianGuo 3,4 1 School of Mathematical Sciences,Beijing Normal University,Beijing 100875,China
In this article, we use penalized spline to estimate the hazard function from a set of censored failure time data. A new approach to estimate the amount of smoothing is provided. Under regularity conditions we establish the consistency and the asymptotic normality of the penalized likelihood estimators. Numerical studies and an example are conducted to evaluate the performances of the new procedure.
This article considers a semiparametric varying-coefficient partially linear binary regression model. The semiparametric varying-coefficient partially linear regression binary model which is a generalization of binary regression model and varying-coefficient regression model that allows one to explore the possibly nonlinear effect of a certain covariate on the response variable. A Sieve maximum likelihood estimation method is proposed and the asymptotic properties of the proposed estimators are discussed. One of our main objects is to estimate nonparametric component and the unknowen parameters simultaneously. It is easier to compute, and the required computation burden is much less than that of the existing two-stage estimation method. Under some mild conditions, the estimators are shown to be strongly consistent. The convergence rate of the estimator for the unknown smooth function is obtained, and the estimator for the unknown parameter is shown to be asymptotically efficient and normally distributed. Simulation studies are carried out to investigate the performance of the proposed method.
In this article, we propose a class of additive-accelerated means regression models for analyzing recurrent event data. The class includes the proportional means model, the additive rates model, the accelerated failure time model, the accelerated rates model and the additive-accelerated rate model as special cases. The new model offers great flexibility in formulating the effects of covariates on the mean functions of counting processes while leaving the stochastic structure completely unspecified. For the inference on the model parameters, estimating equation approaches are derived and asymptotic properties of the proposed estimators are established. In addition, a technique is provided for model checking. The finite-sample behavior of the proposed methods is examined through Monte Carlo simulation studies, and an application to a bladder cancer study is illustrated.
LIU Li 1, MU XiaoYun 2 & SUN LiuQuan 2 1 School of Mathematics and Statistics, Wuhan University, Wuhan 430072, China
