This paper reports petrological and geochemical features and zircon U-Pb age of plagiogranite from the Hongliugou-Lapeiquan ophiolitic melange belt in the northern Altyn Tagh. The zircon U-Pb dating results yield a mean ^238U/^206pb age of 512.1 ± 1.5 Ma, representing an emplacement time of the plagiogranites in the Middle Cambrian. The plagiogranites are interpreted to have derived from anatexis of hydrated amphibolites by ductile shearing during transports of the oceanic crust. Thus it is believed that the formation age of such type of plagiogranite was coeval to or slightly younger than the spreading of the Hongliugou-Lapeiquan limited oceanic basin. The new results from the plagiogranites suggest that an oceanic basin existed in the northern Altyn area during the Middle Cambrian.