The thermokinetic properties of the action of two kinds of lanthanum complexes [La(Hsal)2·(tch)]·2H2O and La(Hsal)2·(hq)(Hsal= C7H5O3,tch= C4H6NO2S,hq =C9H6NO)on growth metabolism of Escherichia coli were studied by a TAM air isothermal calorimeter at 37.00℃.The maximum heat output power Pmax,growth rate constant k,generation timestG,inhibitive ratio I(%) and half inhibition concentration cI,50,were obtained respectively.The results showed that complex[La(Hsal)2·(tch)]·2H2O possessed the bi-directional biological effect.It inhibited the growth of the E.coli at lower concentration but stimulated the growth at higher concentration.The complexes La(Hsal)2·(hq) possessed inhibitory effect.Inhibitory effect of La(Hsal)2·(hq)(cI,50=1.81 mg·L-1) was stronger than that of [La(Hsal)2·(tch)]·2H2O(CI,50=9.78mg·L-1).