We reported four fluorescent chemosensors containing tryptophan units.The fluorescence spectrum titration experiments suggest that chemosensors 1,2,3 and 4 are highly selective for Cu2＋ and Fe3＋ over Li＋,Na＋,K＋,Co2＋,Zn2＋,Ni2＋,Hg2＋ and Cr3＋ via forming complexes with Cu2＋ or Fe3＋,which is confirmed by dramatical quench of fluoreseence in aqueous solution at pH 7.4,thus making all the chemosensors suitable for Cu2＋ and Fe3＋ fluorescent sensors.
CHENG Peng-feiXU Kuo-xiYAO Wen-yongKONG Hua-jieKOU LiMA Xiao-danWANG Chao-jie
A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons. The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines （e.g., L I 210, HeLa and B16） and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B 16 cell line. Of these compounds, 6c show significant cytotoxicity on L 1210, HeLa and B 16 cell lines （IC50 value, 3.74 μmol/L, 5.66μmol/L and 4.04 μmol/L, respectively）. The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.
Jian Hong Wang Jun Jun Zhou Song Qing Xie Qian Li Jin Zhao Chao Jie Wang
