＜正＞ Aminonucleosides are very important intermediates in the synthesis of anti-sense and anti-gene drugs, nucl...
QU, Gui-Rong LIU, Qi-Bin(Key Laboratory of Environmental Science and Technology of High Education of Henan Province, College of Chemical and Environmental Science , Henan Normal University, Xinxiang 453002)
5-Azacytosine (4-amino-1,2-dihydro-1,3,5-triazin-2-one) is a very important intermediate in the synthesis of 5-azacytidine which shows remarkable bacteriostatic and cytostatic activity as well as against T-4 lymphoma and L1210 leukemia in mice. Starting with N-cyanoguanidine (dicyandiamide) and formic acid, under the solvent-free microwave activation, we synthesized 5-azacytosine in short time (4 min) with good yield (60.4%). The structure of the product was confirmed by 1H NMR and elemental analysis.……
Aminonucleosides are very important intermediates in the synthesis of anti-sense and anti-gene drugs, nucleic acid analogues, diagnostic and analytical agents, antitumor and antiviral compounds. In the presence of Raney nickel, the reduction of various azidonucleosides to the corresponding aminonucleosides is in good yields (Table 1,Scheme 1).……
＜正＞ 5-Azacytosine （4-amino-1 ,2-dihydro-1, 3,5-triazin-2-one） is a very important intermediate in the synthesi...
QU, Gui-Rong LIU, Qi-Bin ZHANG, Wen-Sheng Feng, Feng(Key Laboratory of Environmental Science and Technology of High Education of Henan Province ,College of Chemical & Environmental Science , Henan Normal University, Xinxiang 453002)(Department of Chemistry, Jiaozuo Normal College , Jiaozuo 454151)
