To proceed from sensation to movement, integration and transformation of information from different senses and reference frames are required. Several brain areas are involved in this transformation process, but previous neuroanatomical and neurophysiological studies have implicated the caudal area 7b as one particular component of this transformation system. In this study, we present the first quantitative report on the spatial coding properties of caudal area 7b. The results showed that neurons in this area had intermediate component characteristics in the transformation system; the area contained bimodal neurons, and neurons in this area encode spatial information using a hybrid reference frame. These results provide evidence that caudal area 7b may belong to the reference frame transformation system, thus contributing to our general understanding of the transformation system.
Hui-Hui JIANGYing-Zhou HUJian-Hong WANGYuan-Ye MAXin-Tian HU
To proceed from sensation to movement,integration and transformation of information from different senses and reference frames are required.Several brain areas are involved in this transformation process,but previous neuroanatomical and neurophysiological studies have implicated the caudal area 7b as one particular component of this transformation system.In this study,we present the first quantitative report on the spatial coding properties of caudal area 7b.The results showed that neurons in this area had intermediate component characteristics in the transformation system;the area contained bimodal neurons,and neurons in this area encode spatial information using a hybrid reference frame.These results provide evidence that caudal area 7b may belong to the reference frame transformation system,thus contributing to our general understanding of the transformation system.
Hui-Hui JIANGYing-Zhou HUJian-Hong WANGYuan-Ye MAXin-Tian HU
利用心得安阻断β-肾上腺素受体(β-受体),从而干扰药物成瘾患者对药物环境线索记忆的某些环节(如再巩固等),进而降低或抑制其对成瘾药物的渴求,已成为未来治疗复吸的潜在途径。但目前,心得安对吗啡相关环境线索记忆的获得及提取的影响尚不清楚。因此,该实验检测了心得安对小鼠吗啡诱导的条件化位置偏爱(conditioned place preference,CPP)环境线索记忆的获得和提取的影响。该研究首次发现在吗啡CPP记忆的获得期,心得安不影响CPP的表达和消退,提示β-受体不参与吗啡诱导CPP学习记忆的获得;而在吗啡CPP记忆的提取期,心得安可延缓CPP的消退,提示β-受体与吗啡诱导CPP学习记忆的提取相关。该结果表明,药物成瘾过程与β-受体相关,为成瘾等精神疾病的治疗提供了新的理论依据。
