Three new caryophyllene sesquiterpenoids,cytosporinols A-C(1-3),have been isolated from solid cultures of Cytospora sp.The structures of 1-3 were elucidated primarily by NMR spectroscopy,and 3 was further confirmed by X-ray crystallography.The absolute configurations of the C-11 secondary alcohol in 1 and the 6,8-diol moiety in 3 were deduced using the modified Mosher and Snatzke’s method,respectively.Compounds 2 and 3 showed moderate cytotoxicity against HeLa cells.
Yan LIChang-Wei LICheng-Bin CUIXing-Zhong LIUYong-Sheng CHE
