Vortex-induced vibration(VIV)of a stay cablesubjected to a wind profile is numerically simulatedthrough combining computational fluid dynamics(CFD)code CFX 10.0 and computational structural dynamics(CSD)code ANSYS 10.0.A stay cable with the inclinedangle of 30°is used as the numerical model.Under aprofile of mean wind speed,unsteady aerodynamic liftcoefficients of the cable have been analyzed in both timedomain and frequency domain when VIV occurs.Theresults indicate that the lift coefficient wave response of thestay cable under a wind profile is different from that of aninfinitely long cable under a uniform flow in water(i.e.,without consideration of profile)obtained by directnumerical simulation.Cable oscillations can severelyaffect the unsteady aerodynamic frequencies,changeflow field distribution near the cable and affect the vortexshedding in the wake.