病毒入侵机体后,会被天然免疫系统所识别,进而引发天然免疫信号通路的活化产生一型干扰素(IFNα/β)和一些炎性细胞因子如IL-1β。目前研究发现,病毒入侵信号主要由一类模式识别受体识别,包括Toll样受体(Toll like receptors,TLRs)、RIG-I样受体(RIG-I like receptors,RLRs)、Nod样受体(Nod like receptors,NLRs)、Hin-200家族蛋白及一些DNA受体,这些受体介导一型干扰素及炎性细胞因子的产生,并受到多种严格的调控机制调控。该文将对模式识别受体介导的抗病毒天然免疫信号转导通路及相关调控分子机制做一综述。
Caspases are a family of cysteine proteases whose functions have been scrutinized intensively in recent years.Beyond their established roles in programmed cell death and inflammatory response,some caspases are also fundamental players in antiviral immunity by fine-tuning the levels of antiviral signaling adapters and cytokines,such as type I interferons,which serves as a major,sophisticated weapon against viruses.Viral infections can result in inflammasome activation and the initiation of cell death,including apoptosis and pyroptosis,and multiple caspases are significantly involved in these processes.This review will focus on the cutting-edge discoveries regarding the multifaceted roles of caspases in antiviral innate immunity.
