A practical chemical synthesis of L-camitine （1） has been accomplished from （R）-3-chloro-1,2-propanediol （（R）-4）, which is a main by-product originated from （R,R）-Salen Co（III） catalyzed hydrolytic kinetic resolution （HKR） of （±）-epichlorohydrin. （R）-4 was utilized as a chiral starting material to prepare the key intermediate cyclic sulfite （（R）-S）. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of bioactive compounds.
Xu Qin Li Yun Xu Yang Wei Li Wang Bin Hu Hui Min Xue Tian Yi Zhang Xue Tao Zhang
A quinoline derivative N-（2-hydroxyl-naphthylmethyl）-N-（quinol-8-yl）amine（2） was synthesized and characterized, which can selectively recognize Cu^2＋ over other metal ions such as Zn^2＋, Cd^2＋, Sn^2＋, Pb^2＋, Hg^2＋, Ni^2＋, Mg^2＋, Cr^3＋, Mn^2＋, Sr^2＋, K^＋, Ca^2＋, Na^＋, Ba^2＋ in acetonitrile/water（volume ratio 99：1）. Cu^2＋ induced a new absorption peak at 464 nm in the absorption spectrum（ε=4.66×10^2 L·mol^-1·cm^-1） and quenched the fluorescence emission of quinoline derivative 2. The binding of quinoline derivative 2 to Cu^2＋ was in 1 ： 1 model and stable constant was esti- mated to be 2.48×10^5 L·mol^-1.
FAN Cai-lingDAI XingYANG Wu-minWANG Xing-fengYANG Yun-xu
