Curcuphenol is an interesting sesquiterpenoid with diverse bioactivities. Exploration of a concise and scalable synthetic route is still of significance in spite that many asymmetric total syntheses have been achieved. We report an expedient asymmetric synthesis of （R）-curcuphenol from citronellal, which features only two purification opera- tions in the overall six-step synthesis.
First total synthesis of norleucosceptroids F and G has been achieved through key steps of Michael-AIdol cascade, oxa-Michael cyclization-dehydration-deprotection cascade and cross metathesis （CM）, this work developed a general and concise method to the synthesis of leucosceptroid and norleucosceptroid.
A dual-site fluorescent probe with double bond and aldehyde as reactive sites, was designed for the selective detection of sulfite and biothiols. Sulfite reacts with conjugate bond selectively, while Cys responses with aldehyde and GSH occurs substitution reaction. Different interactions cause different absorption and fluorescence responses. Moreover, it could be further applied in imaging in living cells.
