A new compound named 13b (S )-hydroxy-17c-ethoxypheaophorbide a (2) together witha known compound 17c-ethoxypheaophorbide a (1) were isolated from marine sponge Dysidea sp.collected in South China sea. The structures were elucidated by spectroscopic analysis as well ascomparison with those reported in literatures.
Two new compounds, namely 7α, 10α-dimethyl-3β-isopropene-1, 2-ene-octahydro- naphthalene (1) and ethyl 5Z,8Z,11Z,14Z-nonadecatetraenoate (2) were isolated from the soft coral Nephthea hainansis. Compound 1 was a pseutosesquiterpene and 2 was a polyunsaturated fatty acid ethylate. Their structures were established on the basis of spectroscopic methods.
From the marine sponge Jaspis sp., a new isomalabaricane triterpenoid 22, 23- dihydrostellettin D (1) was isolated, and its structure was established on the basis of IR, MS and extensive 2D NMR spectroscopic analysis. It is a unique skeleton compound rarely obtained from Chinese marine organisms.
The antiproliferative activity and underlying mechanisms of jaspolide B, an isomalabaricane-type triterpene, isolated from the sponge Jaspis sp., were investigated using human promyeloleukemic HL-60 cells. Jaspolide B arrested HL-60 cells in the G2/M phase of the cell cycle and induced apoptosis of HL-60 cells in a dose- and time-dependent manner. Moreover, the poly （ADP-ribose） polymerase （PARP） protein was cleaved by jaspolide in a dose- and time-dependent way. Jaspolide B with an ICs0 value of 0.61 μmol/L was found to be comparable efficacy as that of paclitaxel （IC50：0.78 μmol/L）. These results implicate the potential ofjaspolide B as a promising anticancer agent in chemotherapy of leukemia by arresting cell cycle progression at G2/M phase and triggering apoptosis.
