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国家自然科学基金(91130009)

作品数:16 被引量:43H指数:4
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16 条 记 录,以下是 1-10
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基于扩散矩阵的半监督回归学习被引量:2
2014年
半监督学习算法用到标记和未标记的样本.大量的实验表明,利用无标记样本可以改进学习算法的逼近性能.然而,当样本数增加时,逼近性能的定量分析几乎没有.本文构造基于扩散矩阵的一种半监督学习算法,建立逼近阶.结果还量化地说明,未标记样本的使用可以减少逼近误差.
陈珩吴纪桃陈迪荣
关键词:半监督学习回归函数
基于MADS-box诱饵与蛋白质相互作用的拟南芥花瓣发育分子网络拓展被引量:1
2015年
阐明花器官发育调控机理具重要的进化、发育和生态学意义。该文以拟南芥(Arabidopsis thaliana)花瓣发育为例,整合蛋白质互作、亚细胞定位、基因芯片和基因功能注释等数据库,通过组建蛋白质互作可信预测模型,获得拟南芥花瓣蛋白质互作网络,以含有MADS-box结构域蛋白为诱饵在网络中进行一级拓展,得到含38个蛋白质和67对互作的拓展网络。基于拓展网络,DAVID基因功能注释表明,多数蛋白质涉及的生物学过程与花发育调控相关;提取到19个候选四元互作,涉及ABCDE模型基因之外的8个基因,其中含MADS-box结构域的AGL16可能是B类基因新成员或其冗余;SEU、LUH、CHR4、CHR11、CHR17和AT3G04960为拟南芥花瓣AP1-AP3-PI-SEP四聚体的候选靶标基因。研究结果为深入解析拟南芥花瓣发育分子调控网络奠定了基础。
杨黎孙丛苇代志军何淼袁哲明
关键词:拟南芥MADS-BOX蛋白质相互作用
Improved Sampling and Reconstruction in Spline Subspaces被引量:2
2016年
As a special shift-invariant spaces, spline subspaces yield many advantages so that there are many practical applications for signal or image processing. In this paper, we pay attention to the sampling and reconstruction problem in spline subspaces. We improve lower bound of sampling set conditions in spline subspaces. Based on the improved explicit lower bound, a improved explicit convergence ratio of reconstruction algorithm is obtained. The improved convergence ratio occupies faster convergence rate than old one. At the end, some numerical examples are shown to validate our results.
Jun XIANSong LI
The bounds of restricted isometry constants for low rank matrices recovery被引量:6
2013年
This paper discusses conditions under which the solution of linear system with minimal Schatten-p norm, 0 〈 p ≤ 1, is also the lowest-rank solution of this linear system. To study this problem, an important tool is the restricted isometry constant (RIC). Some papers provided the upper bounds of RIC to guarantee that the nuclear-norm minimization stably recovers a low-rank matrix. For example, Fazel improved the upper bounds to δ4Ar 〈 0.558 and δ3rA 〈 0.4721, respectively. Recently, the upper bounds of RIC can be improved to δ2rA 〈 0.307. In fact, by using some methods, the upper bounds of RIC can be improved to δ2tA 〈 0.4931 and δrA 〈 0.309. In this paper, we focus on the lower bounds of RIC, we show that there exists linear maps A with δ2rA 〉1√2 or δrA 〉 1/3 for which nuclear norm recovery fail on some matrix with rank at most r. These results indicate that there is only a little limited room for improving the upper bounds for δ2rA and δrA.Furthermore, we also discuss the upper bound of restricted isometry constant associated with linear maps A for Schatten p (0 〈 p 〈 1) quasi norm minimization problem.
WANG HuiMinLI Song
HIV辅助受体CCR5常见小分子抑制剂抑制效果的综合评价被引量:8
2012年
通过系统比较CCR5常见小分子抑制剂的抑制效果,寻找CCR5的优化对接靶点,筛选最优抑制剂,为新型抑制剂的研发提供理论依据。基于Material Studio软件,我们构建了7类29种小分子抑制剂的三维结构,全面模拟了各种抑制剂与CCR5对接的效果;利用分子对接绝对自由能、相对自由能、对接姿态百分比和Lib-Dock综合得分等参数评估小分子抑制剂的抑制效果。研究初步发现,CCR5小分子抑制剂的最优对接位点是第二个胞外环与N末端之间的site4。小分子抑制剂的抑制效果由强到弱排序依次为:抑制剂27(吡咯烷类)、抑制剂8(苯并环庚烯类)、抑制剂12(哌啶类)、抑制剂14(螺环二酮哌啶类)、抑制剂21(4-哌啶-1-丁胺类)、抑制剂5(天然小分子类)和抑制剂17(托品烷类);其研究表明,吡咯烷类抑制剂27可能成为CCR5最优抑制剂候选对象。
焦诗卉何淼
关键词:DISCOVERYSTUDIOCCR5HIV-1小分子抑制剂
相互近邻域的函数型回归估计
2014年
令H为可分的希尔伯特空间,(X,Y)是在H′i上取值的随机对。本文通过对每个iX进行d项傅里叶级数展开,从而将无穷维降到有限维,进而证明了MNN估计的相容性。其中维数和邻域数都是从观察样本中自动选取的。
黄收友
关键词:希尔伯特空间回归函数相容性
Block Sparse Recovery via Mixed l_2/l_1 Minimization被引量:10
2013年
We consider efficient methods for the recovery of block sparse signals from underdetermined system of linear equations. We show that if the measurement matrix satisfies the block RIP with δ2s 〈 0.4931, then every block s-sparse signal can be recovered through the proposed mixed l2/ll-minimization approach in the noiseless case and is stably recovered in the presence of noise and mismodeling error. This improves the result of Eldar and Mishali (in IEEE Trans. Inform. Theory 55: 5302-5316, 2009). We also give another sufficient condition on block RIP for such recovery method: 58 〈 0.307.
Jun Hong LINSong LI
拟南芥花模式建成多阶段遗传机制
2022年
花是被子植物的繁殖器官,探究花模式建成对植物进化、形态发育和作物育种等领域的研究均具有十分重要的科学意义。本文所用数据来源于拟南芥(Arabidopsis thaliana)信息资源数据库,包括79个样本的261个基因芯片数据;采用支持向量机算法构建了拟南芥花发育三阶段的蛋白质相互作用网络;利用功能富集分析、网络拓扑结构分析和聚类分析,挖掘出一批与拟南芥花形态发育和花器官形成相关的潜在重要功能基因;基于完善花发育经典的ABCD理论模式,初步阐释了拟南芥花发育的多阶段网络遗传机制。
何均泽张蒙钟华文何淼
关键词:拟南芥蛋白质相互作用网络
基于随机投影的回归分析被引量:4
2016年
设(X,Y)是F×R上的随机对,其中F为可分的半度量空间.基于广泛应用背景,本文研究的是回归函数r(x)=E[Y|X=x]的最近k-邻域核估计函数r n(x)的收敛问题.通过运用随机投影的方法,本文对函数型数据的最近k-邻域进行回归分析,并得到了其相应的相容性.
黄收友陈迪荣
关键词:回归函数相容性
A Prospective Approach for Exploring Potential Biofuel Plants
2013年
Biofuels are indeed clean, green, renewable and sustainable, which have a great effect on alleviating social energy crisis as they can be extracted from various kinds of biomass. According to the crucial enzymes involved in the synthesis of sucrose, starch and lipid, various combinations of crucial enzymes were used to retrieval in NCBI (the National Center for Biotechnology Information) database to screen out species with high similarities. Moreover, comprehensive evaluation formulas were designed to excavate potential biofuel plants, which considered several parameters including the homology index, availability rate, distribution area in China, price index and function index. Finally, tens of superior plant species, for example, Panicum virgatum, Zeal luxuriant and Brassica napus, are suggested to be the potentials in future biofuels productions. These plants have the characteristics of wide distribution, high yield, and low cost in production, and they are useful for environmental protection as well as sources of non-crop biomass fuels in China. The results provide a theoretical basis for further study and exploitation of biofuels.
Shubo ZhangJing LiuXiaobai JinDaniel Wai Tin ChanMiao He
关键词:SUCROSESTARCH
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