A new series compounds, α-methylene-β-carboxy-γ-thiobutyrolactones, have been prepared and their biological evaluation in vitro and in vivo have been described. The structures of these compounds were confirmed by ^1H NMR and FAB-MS spectra.
The asymmetric synthesis of （-）-（4R, 5R）-4-[5-（benzo[1, 3]dioxol-5-yl）-4-hydroxyl-1- （pyridin-2-yl）-4,5-dihydro-lH-pyrazol-3-yl]-benzamide with improved Juliá-Colonna asymmetric epoxidation procedure as key step was described.
A series of novel aromatic-linked polyamine macrocyclic derivatives have been synthesized. Their structures were confirmed by MS and ^1H NMR. These compounds exhibited potent anti-HIV-1 activities.
Jing SuYao LiuZhi Bing ZhengJun Hai XiaoHong LuWu ZhongLi Li WangShi Bo JiangSong Li
