Digital signature has recently played an increasingly important role in cyberspace security.Most of them are based on the public key cryptography.Public key cryptography is a mainstream cryptographic algorithm system that has been widely used in cyberspace security in recent years.The most classic public key cryptography algorithm is RSA and its difficulty is based on the large integer decomposition problem.In 2017,ISRSAC was proposed by M.Thangaval.ISRSAC has made security improvements to the RSA algorithm by increasing the complexity in factoring the value of modulus‘n’.A digital signature algorithm based on ISRSAC algorithm was completed in this paper,and furthermore,a proxy signature algorithm based on ISRSAC and two kinds of multi-signature algorithms were presented,which include sequential multi-signature and broadcasting multi-signature.