Objective： To observe the relaxant effect of Aike Mixture （艾可合剂, AKM） on isolated bladder and prostatic urethral smooth muscle of rabbits. Methods： The isolated bladder and prostatic urethral smooth muscle from male rabbits were placed Jn a Magnus bath and smooth muscle contraction was measured using a biological signal acquisition and analysis system. The effects of AKM in combination with methoxyamine, carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing. Results： AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle （r=0.831, P〈0.05）, reduced contractile wave amplitude （r=0.837, P〈0.05） and decreased contractile frequency （r=-0.917, P〈0.01）. AKM signJfJcantly inhibited the increases in smooth muscle contraction induced by methoxyamine, carbachol and CaCl2. Conclusion： AKM dose-dependently inhibited the contraction of rabbit isolated bladder and prostatic urethral smooth muscle by antagonizing α1-adrenergic receptors and M-cholinergic receptors.
Objective：To observe the effect of Aike Mixture（艾可合剂,AKM） on prostatic inflammatory infiltration in patients with chronic prostatitis typeⅢA（ⅢA-CP/CPPS） and evaluate its anti-inflammatory action. Methods：A total of 60 patients with 1 A-CP/CPPS suitable to operation and differentiated as Chinese medicine Gan（肝）-qi stagnancy syndrome type were selected.They were assigned with the random number table to two groups equally.Before operation,the patients in the treated group were administered with Proscar combined with AKM,but those in the control group treated with Proscar only.Suprapubic transvesical prostatectomy was performed two weeks later,and prostatic pathological examination was conducted.Results：Grading of inflammatory cell infiltration showed that the mean grade in the treated group was 0.78±0.90 grades,which was sihnificantly lower than that in the control group 1.68±0.87 grades（P〈0.05）.However,the two groups were not different in the grades of fibroblast proliferation（1.50±0.70 grades vs 1.62±0.87 grades,P〉0.05）.Conclusion： AKM could suppress the inflammatory cell infiltration,be an effective and safe remedy for the treatment ofⅢA-CP/ CPPS of Gan-qi stagnancy syndrome type,and worthy for spreading in clinical use.
