线上线下混合式教学是一种线上教学与课堂教学有效整合的教学模式。雨课堂作为一种智慧型教学工具,为天然药物化学改革带来新的体验。文章分析了天然药物化学的教学现状,结合继续教育学院药学/药物制剂专升本学生学习特点,以天然药物化学第五章“黄酮类化合物”为例,分别从教学内容、教学目标、教学设计、考核评价等方面,探讨雨课堂教学模式在天然药物化学中的具体应用,为其他药学专业课程的改革提供参考。Blended online and offline teaching is a teaching model that effectively integrates online and classroom teaching. Rain classroom, as an intelligent teaching tool, brings new experiences to the reform of medicinal chemistry of natural products. The article analyzes the current teaching situation of medicinal chemistry of natural products, combined with the learning characteristics of pharmacy/pharmaceutical preparation undergraduate students in the continuing education college. Taking chapter five “flavonoids” of medicinal chemistry of natural products as an example, it explores the specific application of the rain classroom teaching mode in medicinal chemistry of natural products from the aspects of teaching content, teaching objectives, teaching design, and assessment evaluation, providing reference for the reform of other pharmaceutical professional courses.